NIH R01 · 2025
Novel Inhibitors for Temporal Modulation of T-Lymphocytes during Chronic Heart Failure
Project Summary Inflammatory immune responses dictate cardiac healing post-myocardial infarction (MI) and are temporally regulated to initiate wound-healing and scar formation. Recent studies have shown that, in addition to immediately after myocardial infarction (MI), circulating, splenic and cardiac inflammatory cells (monocytes, macrophages, and T-lymphocytes) are augmented even at 8-weeks post-MI (chronic HF), and promote pathological left ventricular (LV) remodeling. Moreover, we and others have shown that depletion of specific cell types, including monocytes/macrophages or T-cells during chronic HF blunts LV remodeling and prevents progressive decline in cardiac function, suggesting a…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.