NIH R01 · 2025
Onco-immunologic factors contributing to OPSCC among people living with HIV
Oropharyngeal cancer (OPC) is a type of head and neck cancer and ~70% cases of OPC are associated with high-risk (hr) human papillomaviruses (HPV) infection. OPC cancers are increasing in prevalence especially in persons living with HIV (PWH) and this group also has higher rates on HPV associated OPC. Reasons for these findings are not well understood. While antiretroviral treatment (ART) does diminish HIV replication and immune activation, in a large majority of PWH it is generally started in chronic infection, when HIV reservoirs have already been established and uncontrolled HIV replication has resulted in significant immune dysfunction. Based on our preliminary data and what is known in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.