NIH R01 · 2024
CalR: A toolkit and repository for experiments of energy homeostasis using indirect calorimetry
Project Summary Modern indirect calorimetry systems allow for high-density multi-dimensional time-series measurements of components affecting body weight and energy homeostasis. Indirect calorimetry is used for understanding the factors influencing pathogenic changes to body weight—examples include weight loss with cancer cachexia, or weight gain with obesity. These indirect calorimetry systems generate a flood of raw data that requires time- consuming manual manipulation for formatting, data cleaning, quality control, and visualization. Beyond data handling, analysis of indirect calorimetry experiments requires specialized statistical treatment to account for differential contributions of…
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