NIH R01 · 2025
Genetically-encoded tools that provide researchers with a means to control neural activity in genetically-defined cell types are widely used to establish causal relationships between neural activity and behavior. Current tools for silencing synaptic output in a way that is restricted to anatomically-defined target nuclei in the brain suffer from technical drawbacks that limit their widespread use by the neuroscience community. Optogenetic silencing tools are either prone to artifacts or demonstrate limited efficacy. Although chemogenetic tools such as the hM4Di Designer Receptors Exclusively Activated by Designer Drug (DREADD) appear to be highly effective in multiple cell classes,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.