NIH R01 · 2024
ABSTRACT Parkinson’s disease (PD), Alzheimer’s disease and related dementias (AD/ADRD) are debilitating progressive neurodegenerative diseases. These diseases have no effective treatments currently and are among the greatest unmet challenges in healthcare today affecting millions of people globally with enormous economic and societal burdens. These disorders are characterized by neurodegeneration among other pathologies. A highly conserved, yet less understood family of human genes, Tubulin Polymerization Promoting Proteins (TPPP), has long been implicated in PD and ADRD such as Lewy Body Dementia. However, the pathogenic mechanisms involving TPPP remain unknown. We recently developed a…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.