NIH R01 · 2024
Pregnancy-Specific Mechanisms Regulating Beta-Cell Proliferation and Mass
Gestational diabetes (GDM), or hyperglycemia that first manifests during pregnancy, worsens pregnancy outcomes and long-term health risks for both a mother and her offspring. As with all types of diabetes, a relative insufficiency of functional pancreatic β-cells is a fundamental defect contributing to GDM. Normally, β-cells adapt to the metabolic challenges of pregnancy by expanding β-cell mass. This expanded mass regresses in the postpartum period. Thus, pregnancy is a unique physiologic condition that occurs in a fully-developed adult and requires rapid, dynamic changes in β-cell mass. Unfortunately, the mechanisms of normal gestational β-cell adaptation and the defects underlying GDM…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.