NIH R01 · 2025
Genetic variation underlying innate lymphoid cell phenotypes across hosts
Project Summary Maintenance of gut epithelial homeostasis requires signals from a specialized set of RORγt+ innate lymphoid cells (ILCs) that reside in mucosa. RORγt+ ILCs directly regulate the gut barrier by secreting cytokines that activate epithelial host defense mechanisms and reinforce gut barrier integrity. Among the RORγt+ ILCs, there exists a set of phenotypically diverse cells characterized by distinct patterns of cytokine secretion, transcription factor expression, and physical distribution. Although a comprehensive understanding of the diversity of RORγt+ ILCs is required to mechanistically determine how to manipulate these cells, the full spectrum of ILCs remains to be examined.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.