NIH R01 · 2025
Mechanisms of p300 Activation During Pluripotency and Differentiation.
SUMMARY Pluripotency is a critical model for understanding fundamental principles of cell fate specification. This process makes selective use of enhancers, regulatory elements that facilitate the transcription of cell-type specific genes. Although changes in enhancer activity are predicted to have broad developmental and pathological implications, we currently have limited understanding of how enhancers regulate development and disease, in part due to our incomplete understanding of the mechanisms by which enhancers regulate gene expression. Increased understanding of the molecular events that regulate enhancer activity, particularly under developmental contexts, will provide important…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.