NIH R01 · 2024
Understanding the Behavior of Novel IL13Ralpha2-directed T cell Engager for GBM
Glioblastoma (GBM) remains incurable cancer with a dismal survival rate despite aggressive multimodal therapy that can include surgery, radiation, chemotherapy, and tumor-treating fields. The failure to improve outcome in GBM patients underscores an urgent need to develop new targeted therapies. Bi-specific T cell engager (BiTEs) proteins promote specific killing of cancer cells by activated T cells via BiTE binding to both T-cells and tumor cells. Because this type of therapy is at an early stage of development for solid tumors such as GBM, our knowledge of tumor uptake, pharmacokinetics, and mechanism of action is limited, which hinders the rational design of clinical studies for…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.