NIH R01 · 2024
Top-down modulation of the dorsal cochlear nucleus
PROJECT SUMMARY An animal’s survival depends on their accurate perception of biologically relevant sounds in a complex hearing environment that is awash with background noise. Top-down contextual information modulates the processing of bottom-up sensory signals at multiple levels of the auditory pathway to improve hearing accuracy, but the neural mechanisms underlying this essential function remain unclear, especially at the earliest processing level in central auditory system. Here we examine the role of the massive top-down projection from the inferior colliculus (IC) to the dorsal cochlear nucleus (DCN). Our overarching hypothesis is that top-down signals that encode contextual…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.