NIH R01 · 2024
Restoration of ependymal integrity reduces posthemorrhagic hydrocephalus in preterm neonates
Abstract About 27% of premature infants weighing less than 1500 g develop intraventricular hemorrhage (IVH). These infants suffer from post-hemorrhagic hydrocephalus, cerebral palsy, and cognitive deficits. No optimal therapy exists to prevent or minimize post-IVH hydrocephalus. IVH damages the multiciliated ependyma in the cerebral ventricles and aqueduct disrupting the cilia-driven CSF flow. Moreover, this inflames the choroid plexus (ChP) and periventricular regions, increasing CSF production and contributing to hydrocephalus. The cerebral ventricle in fetuses is lined by pseudostratified epithelium consisting of radial glia and other neural progenitors. As the brain matures, the radial…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.