NIH R01 · 2024
Programs for generating inhibitory interneuron diversity and connectivity
SUMMARY: Inhibitory interneurons comprise a diverse class of neurons of indisputably high biomedical importance. Interneuron dysfunctions are linked to neuropsychiatric disorders such as autism and schizophrenia and are also implicated in epilepsy and neurodegeneration. Cortical interneurons are born in the ganglionic eminences. As they develop, they migrate to intercalate into diverse cortical circuits throughout the brain, where they become increasingly specialized and modulate many aspects of neural circuit function. Recent transcriptomic and lineage tracing studies have begun to identify new levels of transcriptional diversity among interneuron subtypes and between species. Similarly,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.