NIH R01 · 2025
The role of Tie2 signaling in Aortic Valve Remodeling
Abnormal valve development contributes to many common congenital heart malformations. Developmental signaling events that regulate early valve formation have been studied extensively, however, the mechanisms that underlie latter stages of remodeling to mature valves remain poorly understood. We have recently identified a critical time point at the early stage of semilunar valve remodeling that is fundamental for normal aortic valve formation and have also identified a unique endocardial signaling axis, TIE2-PI3K/AKT- FOXO1, that plays a pivotal role in orchestrating this early remodeling process. Therefore, we propose to 1) Delineate the unique roles of TIE2 signaling in heart valve…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.