NIH R01 · 2025
Comparative analysis of molecular events in mammalian oocytes
Project summary Egg generation entails a unique cell division, Meiosis I (a process also known as oocyte maturation), during which the oocyte acquires its developmental competence. For poorly understood reasons, mammalian oocytes (including human, bovine and porcine oocytes) are notoriously prone to reduced quality. Because oocyte quality is a major determinant of embryo developmental competence and pregnancy success, the long-term research goal of this application is to dissect basic molecular mechanisms that regulate meiosis I in human, bovine and porcine oocytes to understand why female gametes are notoriously prone to reduced quality. Work from our group has demonstrated that…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.