NIH R01 · 2025
CB1-mediated signaling in developmental ethanol effects
Project Summary During pregnancy, alcohol abuse produces persistent changes in the fetal brain, causing behavioral impairments throughout life. These conditions are defined as fetal alcohol spectrum disorder (FASD). Most concerningly, regular binge drinking during pregnancy causes cognitive and socio-behavioral deficits in offspring. However, the molecular mechanisms underlying persistent alcohol-induced neurobehavioral impairments are not fully understood. Our previous studies demonstrated that alcohol exposure results in CB1 signaling defects in neonatal mice (P7) that cause neurodegeneration and behavioral deficits in adults. Other data also implicate CB1 in the teratogenic effects of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.