NIH R01 · 2025
PROJECT SUMMARY Dermal injury leads to fibrosis and scar formation, which can be a significant source of morbidity. Interestingly, humans respond to identical skin injuries with different degrees of scar formation that range from low to high scaring phenotypes. Understanding the mechanisms that drive heterogeneous scarring outcomes will allow us to design strategies to direct wound healing toward regeneration and reduced scarring. Biomechanical forces are known to influence how the skin heals. Biomechanical tension signals fibroblast proliferation, migration, inflammatory functions and production of extracellular matrix (ECM). These responses, in conjunction with oxidative stress in the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.