Bakker Lab

Johns Hopkins University

PSYCHIATRY

Baltimore · United States

NIH-funded
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Research focus

NIH R01 · 2025

Visual hallucinations and memory impairment in Parkinson's Disease: The role of hippocampal networks

PROJECT SUMMARY Parkinson's disease (PD) is diagnosed based on its characteristic motor symptoms of bradykinesia, rigidity, and tremor. Increasingly, neuropsychiatric symptoms are identified as part of the neurodegenerative process of PD. Cognitive impairment and psychosis increase as PD advances and are associated with increased caregiver burden, impaired daily functioning and nursing home placement, dementia, and greater mortality. Specifically, memory impairment and hallucinations occur in a subset of PD patients and are associated with an increased risk for dementia and functional impairment. It is well established that the hippocampus is critically important for memory function and…

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