NIH R01 · 2025
Novel Targets for GI Hormones and Neuropeptides in Regulation of Intestinal Motility
Summary of the Project: Gastrointestinal (GI) motility is a complex group motor behaviors controlled by myogenic, neurogenic, hormonal and additional levels of regulation. Previous research has demonstrated that myogenic regulation is actually accomplished by smooth muscle cells (SMCs), interstitial cells of Cajal (ICC) and cells labeled by antibodies to PDGFRa (PDGFRa+ cells). These cells are electrically coupled, forming a network known as the SIP syncytium. Hormonal regulation has been thought to be due to direct regulation of the excitability of SMCs or to occur indirectly through actions on the enteric nervous system. However, RNAseq of SIP cells sorted to purity by FACS has shown that…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.