NIH R01 · 2024
Inhibition of Radiation-Induced Salivary Gland Fibrosis by Targeting Copper Metabolism
ABSTRACT A first-line treatment for head and neck cancer is radiation therapy, but ionizing radiation can lead to chronic oral complications such as fibrosis of the salivary glands (SG) and xerostomia. Therapeutic strategies to restore SG function include gene therapy, stem cell transplantation and various bioengineering approaches; however, they are dependent on the presence of residual functional SG tissue, a condition not met with full radiation treatment due to extensive fibrotic coverage of the SG. Although a role for Lysyl Oxidase (LOX) in radiation-induced fibrosis has not been investigated in SG, it is notable that each LOX family member has been implicated in various fibrotic…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.