Baker Lab

Univ of North Carolina Chapel Hill

CHEMISTRY

Chapel Hill · United States

NIH-funded
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Research focus

NIH R01 · 2025

Increasing the Coverage, Sensitivity and Specificity of Rapid Lipidomic Measurements

PROJECT SUMMARY/ABSTRACT Lipids are a vital class of molecules that play countless important and varied roles in biological processes. Fully understanding lipid roles, however, is difficult since the number and diversity of lipid species is immense with cells expressing tens of thousands of diverse lipid species. While recent advances in chromatography and high- resolution mass spectrometry have greatly improved our understanding of the potential lipid species present in many different sample types, effectively separating the numerous lipids still remains problematic due to the many isomeric lipids. Isomeric lipid species such as those resulting from subclass isomers, distinct acyl chains…

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