NIH R01 · 2025
PACAP-Dependent Coordination of Glutamate Signaling between Neurons and Astrocytes
Project Summary/Abstract Dysregulation of glutamate signaling is a core component of the pathological basis of drug addiction involving cocaine and many other substances. Recent progress in neuroscience and other fields clearly establishes that the molecular and cellular basis of glutamate-encoded signaling is vastly more complex than previously recognized. In particular, it is becoming increasingly evident that astrocytes, which are among the most abundant cells in the human brain, release glutamate to produce complex regulation over neural circuit activity. This novel form of glutamate-encoded intercellular signaling may be critical to understanding the pathological glutamate produced by…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.