NIH R01 · 2024
Angiogenic hydrogel composites for microvascular integration of organoid grafts
PROJECT SUMMARY/ABSTRACT Graft integration of microvasculature is a critical next step for cell replacement strategies for type I diabetics. The incorporation of host-connected microvasculature is essential for post-implantation graft survival and over the longer-term impacts the kinetics of glucose response and systemic insulin delivery. Directing angiogenesis into islet-containing synthetic hydrogels would guarantee host-connected microvasculature in the graft, but control over angiogenesis remains limited. Our long-term goal is to understand how physical cues from the cellular microenvironment impinge upon critical steps of angiogenesis and devise engineering methods to incorporate these…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.