NIH R01 · 2024
Determinants of H. influenzae Virulence in Otitis Media
PROJECT SUMMARY Despite the relative success of pneumococcal conjugate vaccines (PCVs) against pneumococcal otitis media (OM), the incidence of all-cause OM remains unacceptably high worldwide and broad use of PCVs has also changed the microbiology of OM to one in which nontypeable Haemophilus influenzae (NTHI) predominates. Additionally, whereas the importance of biofilms in OM pathogenesis, chronicity and recurrence is recognized, and the recalcitrance of biofilms to antimicrobials is well accepted, we nonetheless still treat OM with oral antibiotics that do not reach levels in the middle ear required to kill planktonic bacteria, let alone those resident in a biofilm. The use of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.