NIH R01 · 2025
Mitoprotective therapies for kidney injury
ABSTRACT Acute kidney injury (AKI) is a common disease that is associated with adverse short and long-term sequelae. AKI usually occurs in hospitalized patients and in the settings of other clinical conditions, such as sepsis, rhabdomyolysis, and cardiovascular and oncological diseases, where the underlying disease and or associated therapeutic intervention causes abrupt loss of renal function. While the causal mechanisms are incompletely understood, renal tubular epithelial cell (RTEC) dysfunction and cell death is the pathological lesion that initiates and triggers AKI. Importantly, it has now been established that disruption of mitochondrial homeostasis in the early stages of acute…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.