NIH R01 · 2024
Mechanistic Studies of the Type I CRISPR-Cas system
Project Summary Prokaryotes can acquire resistance to viruses and plasmids by integrating short fragments of foreign DNA, called prespacers, into clusters of regularly interspaced short palindromic repeats (CRISPR's). These repeats are then transcribed and processed into small guide RNA's that are used to direct the destruction of foreign nucleic acid. This mechanism has many parallels with eukaryotic RNA interference but the proteins that are associated with the CRISPR response are evolutionarily unrelated to their eukaryotic counterparts. Our long-term goal is to understand the biochemical and structural basis of CRISPR-mediated resistance in prokaryotes. The objectives here are to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.