NIH R01 · 2024
A novel live biologic for the prevention and treatment of NEC-induced neurodevelopmental impairment
SUMMARY: Worldwide, up to 25% of premature infants born prior to 31 weeks gestation, and up to 50% of those born prior to 28 weeks gestation, have neurodevelopmental impairment (NI). The causes of NI are multifactorial, but neuroinflammation is now recognized as a key component. Early life stresses commonly encountered by premature infants, including hypoxia, forced formula feeding, and hypothermia, have the potential to trigger inflammation throughout the body. This inflammation can originate in the intestine, e.g. during neonatal necrotizing enterocolitis (NEC), where the microbiota incite a dysregulated inflammatory response. Excessive inflammation in the periphery propagates…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.