NIH R01 · 2024
Artemisinin Resistance in Africa: its emergence and evolution in Rwanda
ABSTRACT Artemisinin combination therapies (ACTs) are the mainstay antimalarial treatment combating Plasmodium falciparum malaria around the world. While resistance is widespread in Asia, it has not yet been observed in Africa where the majority of the global morbidity and mortality occurs. Artemisinin and ACT resistance in Africa would be a serious setback as there are no next-generation antimalarials ready for deployment. Recent reports in Rwanda of validated artemisinin resistance are of grave concern. A recent therapeutic efficacy study in Rwanda found a high prevalence of patients with delayed parasite clearance, which was associated with a validated artemisinin resistance mutation…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.