NIH R01 · 2025
Determinants of pegivirus persistence and immune control
PROJECT SUMMARY/ABSTRACT Human pegivirus (HPgV) chronically infects approximately 15% of the global human population. Although HPgV does not cause overt disease, we know very little about its biology. Currently, there are no cell culture systems for cultivating HPgV in vitro and no laboratory animals are susceptible to HPgV infection. Recently, we created the first mouse model of PgV infection by adapting a rat pegivirus to infect mice. This mouse-adapted PgV (maPgV) causes high-titer viremia in wild-type mice that persists for hundreds of days without causing overt disease, closely recapitulating key features of HPgV infection. We have also shown that maPgV utilizes a highly novel, albeit…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.