NIH R01 · 2024
Receptor tyrosine kinases (RTKs) represent a family of cell surface receptors. Both of insulin receptor (IR) and type 1 insulin-like growth factor receptor (IGF1R) are type II RTKs that play essential roles in controlling glucose metabolism, cellular growth, proliferation, differentiation, and migration. Aberrant IR or IGF1R signaling causes a number of human diseases, including diabetes and cancers, which makes them promising therapeutic targets. Despite the functional importance and strong connections with diseases, the exact ligand induced activation mechanism of IR and IGF1R are still unknown, due to the lack of high resolution structures of full-length receptors/ligands complex. The…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.