NIH R01 · 2024
Nonalcoholic steatohepatitis (NASH), a cell death and inflammation-associated nonalcoholic fatty liver disease (NAFLD), is the leading cause of hepatocellular carcinoma (HCC) and end-stage liver failure worldwide. There is no effective therapeutic drug for NASH to date, highlighting an urgent need for the identification of novel targets for this devastating disease. Evidence cumulated over the past decade strongly suggest that the innate immune system, specifically the liver-resident macrophages (Kupffer cells) and recruited monocyte-derived macrophages, play a key role in NASH progression and pathogenesis. The current study aims to elucidate the mechanisms by which macrophage cyclic…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.