NIH R01 · 2025
Signaling Pathways that Modulate Neuronal Activity
Project summary G protein-coupled receptor kinases (GRKs) play a pivotal role in modulating neuromodulatory signals by altering GPCRs, with implications for a range of neurological and psychiatric conditions that affect sensation, mood, and movement. The inherent complexity of the GRK protein family, characterized by several similar paralogs and the broad regulation of numerous GPCRs, presents a significant challenge in delineating their functions in vivo. Our research in the nematode Caenorhabditis elegans which has only two GRK paralogs (GRK-1 and GRK-2) has brought to light novel mechanisms of GRK function and specificity. In particular, our studies have found that mutants of grk-2…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.