NIH R01 · 2024
A novel target in aged fracture healing
ABSTRACT Bone fractures occur in 50% of the population causing significant morbidity and mortality and costing more than $20 billion annually. Advanced age diminishes bone repair capacity and is associated with increased surgical intervention at the time of the injury and subsequently with the need for revisions. The development of therapies aimed at enhancing bone repair would significantly reduce the burden on the geriatric population. We recently identified Apolipoprotein E (ApoE) to be an age-associated inhibitor of fracture repair. ApoE is a circulatory protein and increases in abundance with age in mice and in humans. In our published work, circulating ApoE inhibited osteoblast…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.