NIH R01 · 2024
Molecular characterization of biliverdin IXbeta reductase
Project Summary/Abstract Research proposed in this grant application builds on extensive genetic, biochemical and animal studies designed to further characterize and validate biliverdin IXβ reductase (BLVRB) as a novel cellular target regulating human platelet production in situations of stress hematopoiesis, with concomitant effects on erythroid development and repopulation. Although heme degradation is largely studied as a processing pathway designed to clear pro-oxidant (free) heme generated during cellular senescence (or metabolism), heme catabolic enzymes are also known to maintain function(s) in cellular signaling and cytoprotection, and tetrapyrrole byproducts biliverdin (BV) and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.