NIH R01 · 2025
Defining the role of lipid metabolism in nuclear envelope identity and dynamics
PROJECT ABSTRACT The nuclear envelope is a distinct domain of the endoplasmic reticulum (ER) that serves to surround and protect the genome. The unique identity of the nuclear envelope is determined by a subset of integral membrane proteins that execute its distinct functions. After each open mitosis, the nuclear envelope must regain its identity as it forms from ER-derived membranes. In the current funding period, we showed that regulation of the phosphatidic acid phosphatase lipin by the nuclear envelope-enriched protein phosphatase CTDNEP1 restricts ER membrane biogenesis, maintains the lipid composition of the nuclear envelope and contributes to the sealing, size and protein identity of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.