NIH R01 · 2025
PROJECT SUMMARY/ABSTRACT Focal bone marrow biopsies of the posterior iliac crest are the gold standard for diagnosing multiple myeloma, yet they do not reflect the spatial and genomic heterogeneity of the disease. Almost 25% of such patients do not have adequate samples for cytogenetic assessment need for risk stratification. This inconsistency in bone marrow sampling could result in falsely reassuring prognoses for patients with aggressive disease. Whole-body imaging presents an unrealized opportunity to derive image features in the bone marrow that reflect the cytogenetic diversity of clonal plasma cells. Several advanced imaging modalities are used for diagnosis and disease management.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.