NIH R01 · 2024
Unraveling a parabrachial circuit for the state-dependent control of rapid breathing
PROJECT SUMMARY Breathing, unlike most motor behaviors, is under automatic control to ensure homeostasis is maintained. This vital physiological regulation of respiratory activity has been the predominant focus of the control of breathing field. However, in awake animals, breathing is also conditionally modified by changes in behavior and emotion, making it highly dynamic. How these state-dependent control mechanisms allow breathing to conditionally dissociate from its underlying physiological regulation remains far less well understood. In mice, this distinction between automatic and state-dependent respiratory control is exemplified by the rapid breathing frequencies that are unique to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.