NIH R01 · 2025
Biomimetic Vascular Matrix for Vascular Smooth Muscle Cell Mechanobiology and Pathology
SUMMARY Arterial stiffness is a key risk factor for cardiovascular disease (CVD) events. A change in arterial stiffness is a significant pathology in vascular injury, atherosclerosis, and coronary disease. Stiffening of the vessel wall promotes anomalous migration and proliferation of vascular smooth muscle cells (VSMCs), leading to neointima formation on the vessel wall. It is not clear, however, how the extracellular matrix (ECM) influences these pathological processes. This research proposal will address this by exploring how changes in arterial stiffness elicit VSMC behaviors that contribute to cardiovascular disease. Specifically, this work draws upon preliminary data revealing that…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.