NIH R01 · 2024
Integrating Accelerated Droplet Chemistry with LC-MS for High Throughput Quantitative Analysis
Project Summary/Abstract There is an increasing need to improve the characterization of lipids and saccharides for clinical and biomedical research purposes. NMR is the method of choice for obtaining detailed structural information about saccharides. However, NMR typically requires milligram (micromole) quantities of analyte; this often exceeds biologically relevant levels. For lipids, mass spectrometry (MS) provides an efficient avenue for rapid profiling, but quantitative analysis is challenged by difficulty in isolating species of interest due to wide structural diversity. A new MS approach is proposed that fundamentally addresses challenges in quantitative and qualitative MS by…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.