NIH R01 · 2025
Coronary artery dysfunction in OSA: Role of mineralocorticoid receptors
Abstract Obstructive sleep apnea (OSA) is a prevalent condition worldwide, especially in people with obesity, and is an independent risk factor for cardiovascular disease (CVD), including coronary microvascular dysfunction (CMD). Current available OSA treatments have not consistently detected the anticipated improvements in CVD and CMD, suggesting the need for adjuvant therapies aimed at the mechanisms underlying the core disturbances induced by OSA. As such, OSA-induced renin-angiotensin-aldosterone system (RAAS) activation may trigger excessive mineralocorticoid receptor (MR) signaling, which play a major role in endothelial dysfunction and atherosclerosis. Thus, the hypothesis is that…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.