NIH R01 · 2025
Mechanisms and Impact of NRG3 Induction in Bone Metastasis
Without the occurrence of cancer cell dissemination (metastasis), most breast cancer patients would survive following diagnosis and treatment. Alas, cancer cells can disseminate to distant sites long before diagnosis of the primary tumor. Based on clinical investigations, bone is established as the most predominant site of metastasis in breast cancer. Over the years, we started to realize a preferential association of breast cancer subtypes with certain metastatic sites. For instance, hormone receptor- positive (HR+) breast cancer, which represents the most common subtype of breast cancer (65-70%), has a high propensity toward skeletal tissues compared to HR- subtypes (TNBC and HR-/Her2+).…
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