NIH R01 · 2024
Prime shock and kill for HIV erradication
PROJECT SUMMARY When people encounter an infectious agent or a vaccine for the first time, they develop an immune response to that agent or vaccine. Some of the respondent cells may persist for years – even decades, becoming memory T cells, so that if the infectious agent is again encountered, the subsequent immune response can be rapid and exact. Since these cells must to persist for long periods, they have developed mechanisms to resist the normal process of cell turnover, i.e., these cells withstand death signals. HIV infection is a chronic, manageable disease that, as yet, cannot be cured due to the persistence of HIV in memory CD4 T cells that are resistant to cell turnover and death.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.