Backman Lab

Northwestern University at Chicago

NONE

Chicago · United States

NIH-funded
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NIH R01 · 2025

Optical hyperspectral nanoscale chromatin analysis for colon cancer risk-stratification

Colorectal cancer (CRC) is the second leading cause of cancer deaths in the U.S. despite being eminently preventable by colonoscopy. Colonoscopy is the gold standard of CRC screening. Its goal is to identify and remove premalignant adenomatous polyps with the advanced adenoma being the primary target. According to guidelines, colonoscopy is recommended for all patients over the age of 45 (roughly 100 million Americans). However, it is practically impossible to screen this entire eligible population with colonoscopy due to noncompliance, cost, and insufficient resources. As a result, less than half of the population receives colonoscopies as appropriate. The goal of this project is to…

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