NIH R01 · 2024
White matter protection by inhibitors of glial scar formation in perinatal hypoxia ischemia
Project Summary Survivors of preterm birth are commonly diagnosed with persistent white matter injury (WMI) that leads to a failure of normal myelination. Myelination failure results in life long motor and neurobehavioral disabilities. The central feature of WMI is the so-called “glial scar,” an inhibitory barrier generated by reactive astrocytes, which causes myelination failure by blocking the maturation of oligodendrocyte progenitors. It is our long-term objective to develop novel therapies to prevent myelination failure by preventing glial scar formation. There are no therapeutic strategies to prevent early formation of diffuse reactive astrogliosis before it chronically blocks…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.