NIH R01 · 2024
Summary Due to advances in neonatal care, most preterm infants no longer develop cerebral palsy from hypoxic-ischemic white matter injury (WMI). However, up to 50% develop gray matter associated cognitive and learning disabilities by school age that persist throughout life. These developmental disabilities are commonly associated with a systemic hypoxia (Hx) episode arising from lung immaturity, acute respiratory failure or other common complications of prematurity. We have developed a preterm-equivalent mouse model which delivers a single mild clinically relevant episode of Hx at P2. Our preliminary findings support that Hx impairs learning and memory by disrupting hippocampal: (1)…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.