NIH R01 · 2025
Neuronal IL-1R1 Signaling in Mild Closed Head Injury
ABSTRACT The cytokine interleukin-1 (IL-1) is well known to mediate detrimental inflammatory processes in peripheral tissues. IL-1 is elevated in age and in neurodegenerative disease. As a result, IL-1 has become a major focus of anti-inflammatory strategies to treat neuroinflammation following acute injury and in chronic neurodegenerative disease. Surprisingly, there is scant evidence that neurons are damaged through the direct actions of IL-1. To the contrary, a neuron-specific “non-canonical” IL-1 receptor (IL-1R1) pathway that promotes, rather than erodes, neuronal viability has been identified. Despite this paradigm-shifting observation, the non-canonical pathway has received little…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.