NIH R01 · 2025
Single Cell Methods for Bioeffector Discovery and Analysis
PROJECT SUMMARY Natural product therapeutics remain critically important in the treatment of cancer, with most patients diagnosed with cancer receiving natural product-based chemotherapy, such as microtubule disrupting agents and DNA intercalators. Select chemotherapeutic small molecules, the majority of which are natural products, have an additional therapeutic benefit in their ability to stimulate a productive form of natural immunity against the cancer cells that they injure or kill. For example, chemically induced damage associated molecular pattern expression can recruit antigen presenting cells to phagocytose damaged cancer cells and display cancer cell antigens to prime and activate…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.