Babulal Lab

Washington University

NEUROLOGY

Saint Louis · United States

NIH-funded
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NIH R01 · 2025

Life-space, isolation, and functional exposome study in preclinical Alzheimer's disease and cognitive environments (LIFESPACE)

PROJECT SUMMARY/ABSTRACT Alzheimer’s disease (AD) is a global public health priority as nearly 55 million of the world’s population live with dementia, with cases projected to triple to 150 million by 2050. Dementia prevalence varies across populations, and differences are due to complex relationships across demographic and environmental factors. Social isolation may lead to decreased cognitive stimulation, more stress and depression, higher physical inactivity, and increased neuroinflammation among older adults (OA). The overarching goal of this study is to examine and improve the validity and the generalizability of digital signals collected from everyday life, ranging from driving to…

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