Babst Lab

Research focus

NIH R01 · 2025

Plasma membrane stress response

Project Summary The plasma membrane experiences many cellular and environmental changes in form of increasing or decreasing membrane tension. Events such as cytokinesis, cell differentiation, migration, and metabolic changes all affect volume to surface area ratios and thus plasma membrane tension. Therefore, an increasing number of studies identify changes in membrane tension as a common signal for the cellular status. This signal affects cytoskeleton, ion channels, and cell signaling and thus is able to coordinate cellular response pathways. A goal of cellular stress response is to reestablish normal membrane tension, which is important to maintain cell integrity and functionality of…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.