NIH R01 · 2024
Energizing and Protecting Axons Through Metabolic Coupling to Schwann Cells
Axons and their associated glia (Schwann cells and oligodendrocytes) form the largest part of the neuronal network. Axons are challening to maintain energetically and are vulnerable to a wide spectrum of noxious stimuli. Dysfunction of axons and pathological axon degeneration (pAxD) have emerged as a major pathophysiological driver in many neurodegenerative diseases. Consequently, a central therapeutic focus is to develop approaches tailored to protect axons. A prerequisite for such therapies is a better understanding of the autonomous and non- cell autonomous molecular mechanisms that regulate the processes leading to pAxD. Physical disconnection of the axon from the neuronal cell body is…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.