NIH R01 · 2025
Role of carnosine in peripheral arterial disease
Abstract Peripheral arterial disease is a serious manifestation of atherosclerosis in the lower extremities. Current interventions approved by FDA are either ineffective or have a modest effect. Surgical revascularization is the only viable option for PAD subjects; however, the stents can fail. Patients with PAD have marked defects in skeletal muscle metabolism, where the aerobic and anaerobic metabolism are uncoupled, increased acidification of the skeletal muscle and decreased ATP synthesis. In glycolytically active tissue, such as skeletal muscle, there are present histidyl dipeptides, such as carnosine which buffers intracellular pH, under ischemic conditions and facilitate the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.